Description
VitaminEinitsnaturalformisalsoknownasD-α-tocopherol;itexhibitsantioxidative,anti-inflammatory,anti-atherosclerotic,anti-hyperlipidemic,andanti-diabeticactivities.Inkeratinocytes,vitaminEdecreasedUVA-inducedupregulationofIL-8andAP-1bindinganddecreasedactivityofNADPHoxidaseandformationofmalondialdehyde.WhenadmiNISTeredclinically,vitaminEdecreasesROS,lipidoxidation,secretionofIL-1β,andendothelialcell-to-monocyteadhesion.VitaminEisalsoprotectiveagainstretinaledemainanimalmodelsofischemia/reperfusion.Additionally,vitaminEinhibitsintracellularadhesionmolecule1(ICAM-1)-inducedactivationofPKCinendothelialcells.Invivo,thiscompounddecreasesserumtriglycerides,VLDL,PPARγandmalondialdehydelevelsandincreasesPPARαlevels,improvinginsulinresistance.VitaminEalsoinhibitsPKC-DAGsignalingandincreasesglomerularfiltrationrate(GFR)anddecreasesalbuminuria,showingnephroprotectivebenefitinanimalmodelsofdiabeticnephropathy.
References
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