Description
VitaminK3isasyntheticanalogof1,4-naphthoquinone;itisalsoaprecursortovitaminK2.VitaminK3exhibitsanticancer,neuromodulatory,andanti-inflammatoryactivities.Inovariancarcinomacells,vitaminK3inducescaspase8-dependentapoptosis,increaseslevelsofROS,anddecreaseslevelsofglutathione;additionally,vitaminK3bindstubulin,inhibitingmicrotubulepolymerization.Invitro,vitaminK3alsoinhibitsmonoamineoxidasesAandB(MAO-A/B).ThiscompoundincreasesROSandinhibitsleukotrienesecretionbyalteringCa2+influxand5-lipoxygenasesignalinginvitro.
References
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CoelhoCerqueiraE,NetzPA,etal.Molecularinsightsintohumanmonoamineoxidase(MAO)inhibitionby1,4-naphthoquinone:evidencesformenadione(vitaminK3)actingasacompetitiveandreversIBLeinhibitorofMAO.BioorgMedChem.2011Dec15;19(24):7416-24.PMID:22071524.
KawamuraF,NakanishiM,HirashimaN.Effectsofmenadione,areactiveoxygengenerator,onleukotrienesecretionfromRBL-2H3cells.BiolPharmBull.2010;33(5):881-5.PMID:20460770.
AcharyaBR,ChoudhuryD,DasA,etal.VitaminK3disruptsthemicrotubulenetworksbybindingtotubulin:anovelmechanismofitsantiproliferativeactivity.Biochemistry.2009Jul28;48(29):6963-74.PMID:19527023.
