Description
Vitexinisanaturallyoccurringflavonoidfoundinhawthornleaves.Treatmentofdiabeticratswithvitexinhasbeenfoundtoresultinpancreaticisletregeneration,preventionofbeta-celldestruction,andsuppressionoflipopolysaccharide-inducedreleaseofHMGB1protein.PretreatmentofneonatalC57BL/6micewithvitexinprovidedneuroprotectionagainsthypoxic-ischemicbraininjury.Inaddition,vitexinishasshownanti-oxidant,anti-inflammatory,analgesic,andantitumoractivitiesinseveralcancermodelsandcelllines.IthasbeenfoundtoimpacttheJNKMAPKsignalingpathwaytoinhibitgrowthofhepatocellularcarcinomacells.
References
NurdianaS,GohYM,AhmadH,etal.Changesinpancreatichistology,insulinsecretionandoxidativestatusindiabeticratsfollowingtreatmentwithFicusdeltoideaandvitexin.BMCComplementAlternMed.2017Jun2;17(1):290.PMID:28576138.
WangF,YinJ,MaY,etal.Vitexinalleviateslipopolysaccharide-inducedisletcellinjurybyinhibitingHMGB1release.MolMedRep.2017Mar;15(3):1079-1086.PMID:28098903.
MinJW,KongWL,HanS,etal.Vitexinprotectsagainsthypoxic-ischemicinjuryviainhibitingCa2+/Calmodulin-dependentproteinkinaseIIandapoptosissignalingintheneonatalmousebrain.Oncotarget.2017Apr11;8(15):25513-25524.PMID:28424420.
HeJD,WangZ,LiSP,etal.VitexinsuppressesautophagytoinduceapoptosisinhepatocellularcarcinomaviaactivationoftheJNKsignalingpathway.Oncotarget.2016Dec20;7(51):84520-84532.PMID:27588401.
