Description
WHI-P131isaninhibitorofJAK3andEGFRthatexhibitsanticancerchemotherapeutic,chemopreventive,anti-inflammatory,andanti-diabeticproperties.WHI-P131isprophylacticagainstcarcinogenesisinducedbyUVBexposureinvivo,delayinglesionappearanceanddecreasinglesionvolumeandnumber.WHI-P131decreasesplasmacreatinekinaseandlactatedehydrogenaseactivity,decreasinginfarctsize,myocardialapoptosisanddeterioration,andinflammationinanimalmodelsofischemia.Additionally,WHI-P131decreasesTNF-α-inducedexpressionofICAM-1,VCAM-1,andfractalkine,improvingmyocardialpermeABIlityincellularmodels.WHI-P131displayspotentialasaprophylactictreatmentfordiabetes,asitsinhibitionofJAK3andsuppressionofNF-κBresultsindecreasedproductionofNOandiNOS,preventingdestructionofpancreaticisletcells.
References
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UckunFM,DibirdikI,QaziS.PreventionofUVB-inducedskininflammation,genotoxicity,andphotocarcinogenesisinmicebyWHI-P131,adual-functioninhibitorofJanuskinase3andEGFreceptorkinase.Arzneimittelforschung.2010;60(4):218-25.PMID:20486473
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