Description
WogonosideisaflavonoidglycosidefoundintheScutellariaplant;itdisplaysanti-inflammatory,anti-angiogenic,andanticancerchemotherapeuticactivities.Invitro,wogonosidedecreaseslevelsofnitrousoxide(NO)andprostaglandinE2(PGE2)andinhibitsreleaseofpro-inflammatorycytokinesTNF-αandIL-6.Wogonosidealsoincreasesp21anddecreasesc-Myc,ERK1/2,andp38MAPKexpressioninvitro,inducingcellcyclearrestandautophagyinavarietyofcancercelllines.Wogonosideinhibitsvesselgrowthandmigrationinvitroandinvivo,decreasingphosphorylationofJNK,ERK,andp38MAPK.
References
YangYZ,TangYZ,LiuYH.Wogonosidedisplaysanti-inflammatoryeffectsthroughmodulatinginflammatorymediatorexpressionusingRAW264.7cells.JEthnopharmacol.2013Jun21;148(1):271-6.PMID:23612420.
ChenY,HuiH,YangH,etal.WogonosideinducescellcyclearrestanddifferentiationbyaffectingexpressionandsubcellularlocalizationofPLSCR1inAMLcells.Blood.2013May2;121(18):3682-91.PMID:23487022.
SunY,ZouM,HuC,etal.WogonosideinducesautophagyinMDA-MB-231cellsbyregulatingMAPK-mTORpathway.FoodChemToxicol.2013Jan;51:53-60.PMID:23000445.
ChenY,LuN,LingY,etal.Wogonosideinhibitslipopolysaccharide-inducedangiogenesisinvitroandinvivoviatoll-likereceptor4signaltransduction.Toxicology.2009May2;259(1-2):10-7.PMID:19428938.
