Description
Wogonoside is a flavonoid glycoside found in the Scutellaria plant; it displays anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities. In vitro, wogonoside decreases levels of nitrous oxide (NO) and prostaglandin E2 (PGE2) and inhibits release of pro-inflammatory cytokines TNF-α and IL-6. Wogonoside also increases p21 and decreases c-Myc, ERK1/2, and p38 MAPK expression in vitro, inducing cell cycle arrest and autophagy in a variety of cancer cell lines. Wogonoside inhibits vessel growth and migration in vitro and in vivo, decreasing phosphorylation of JNK, ERK, and p38 MAPK.
References
Yang YZ, Tang YZ, Liu YH. Wogonoside displays anti-inflammatory effects through modulating inflammatory mediator expression using RAW264.7 cells. J Ethnopharmacol. 2013 Jun 21;148(1):271-6. PMID: 23612420.
Chen Y, Hui H, Yang H, et al. Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells. Blood. 2013 May 2;121(18):3682-91. PMID: 23487022.
Sun Y, Zou M, Hu C, et al. Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway. Food Chem Toxicol. 2013 Jan;51:53-60. PMID: 23000445.
Chen Y, Lu N, Ling Y, et al. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. Toxicology. 2009 May 2;259(1-2):10-7. PMID: 19428938.
