LKT/黄腐酚/X0254/10毫克-免疫在线蚂蚁淘旗下平台

商品详细LKT/黄腐酚/X0254/10毫克

LKT/黄腐酚/X0254/10毫克

商品编号： X0254-10mg

品牌： lktlabs

市场价： ¥2900.00

美元价： 1740.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDX0254

CasNo.6754-58-1

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Xanthohumol(XN)isaprenylatedflavonoidfoundinHumuluslupulusthatexhibitsanti-osteoporotic,anticancer,anti-inflammatory,atheroprotective,neuroprotective,andestrogenicactivities.XNaltersNF-kBsignaling,decreasesexpressionofpro-inflammatorycytokinesIL-1-βandMCP-1,andactivatedAMP-activatedproteinkinase.Inarodentmodelofcerebralischemia,XNattenuatesfocalcerebralischemiaandimprovedneurobehavioraldeficitsbyinhibitingischemia-relatedincreasesinTNF-α,HIF-1α,iNOS,andfreerADIcalformation.XNalsoinhibitsdifferentiationofpreadipocytesandincreasesapoptosisinmatureadipocytes,potentiallyplayingaroleinlipidmetabolism.Thiscompoundmayalsoplayapreventativeroleagainstbonediseases,asitinhibitsosteoclastogenesisbymodulatingRANKLsignaling.XNalsoinducesapoptosisandindirectlysuppressesNotchsignalinginhepatocellularcarcinomamodels.

ProductInfo

CasNo.	6754-58-1
Purity	≥98%
Formula	C₂₁H₂₂O₅
FormulaWt.	354.40
ChemicalName	(E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
IUPACName	(E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
Appearance	YellowPowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	ambient

Downloads

InfoSheet	X0254InfoSheetPDF

References

KunnimalaiyaanS,SokolowskiKM,BalamuruganM,etal.Xanthohumolinhibitsnotchsignalingandinducesapoptosisinhepatocellularcarcinoma.PLoSOne.2015May26;10(5):e0127464.PMID:26011160.

SuhKS,RheeSY,KimYS,etal.Xanthohumolmodulatestheexpressionofosteoclast-specificgenesduringosteoclastogenesisinRAW264.7cells.FoodChemToxicol.2013Aug27.[Epubaheadofprint]PMID:23994090.

DoddapattarP,RadovićB,PatankarJV,etal.Xanthohumolamelioratesatheroscleroticplaqueformation,hypercholesterolemia,andhepaticsteatosisinApoE-deficientmice.MolNutrFoodRes.2013May3.[Epubaheadofprint]PMID:23650230.

ViolaK,KopfS,RarovaL,etal.Xanthohumolattenuatestumourcell-mediatedbreachingofthelymphendothelialbarrierandpreventsintravasationandmetastasis.ArchToxicol.2013Jul;87(7):1301-12.PMID:23503627.

YenTL,HsuCK,LuWJ,etal.Neuroprotectiveeffectsofxanthohumol,aprenylatedflavonoidfromhops(Humuluslupulus),inischemicstrokeofrats.JAgricFoodChem.2012Feb29;60(8):1937-44.PMID:22300539.

MonteiroR,CalhauC,SilvaAO,etal.Xanthohumolinhibitsinflammatoryfactorproductionandangiogenesisinbreastcancerxenografts.JCellBiochem.2008Aug1;104(5):1699-707.PMID:18348194.

YangJY,Della-FeraMA,RayalamS,etal.Effectofxanthohumolandisoxanthohumolon3T3-L1cellapoptosisandAdipogenesis.Apoptosis.2007Nov;12(11):1953-63.PMID:17874298.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂