XAV-939inhibitstankyrasesandwntpathwaysignaling.XAVexhibitsanti-fibroticactivityandshowspotentialanticancerchemotherapeuticbenefitwhenco-admiNISTeredwithothercompounds.XAV-939decreasesnuclearaccumulationofβ-cateninanddecreasesc-myclevels,decreasingbleomycin-induceddermalthickening.Inbothinvitroandinvivomodelsofcancer,thiscompoundreversesresistancetoPI3KandAktinhibitors.
| CasNo. | 284028-89-3 |
|---|---|
| Purity | ≥95% |
| Formula | C14H11F3N2OS |
| FormulaWt. | 312.31 |
| ChemicalName | 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol |
| IUPACName | 2-[4-(Trifluoromethyl)phenyl]-1,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one |
| Solubility | DMSO(25mg/ml) |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | X0384InfoSheetPDF |
|---|
BilirB,KucukO,MorenoCS.Wntsignalingblockageinhibitscellproliferationandmigration,andinducesapoptosisintriple-negativebreastcancercells.JTranslMed.2013Nov4;11(1):280.[Epubaheadofprint].PMID:24188694
DistlerA,DelochL,HuangJ,etal.InactivationoftankyrasesreducesexperimentalfibrosisbyinhibitingcanonicalWntsignalling.AnnRheumDis.2013Sep1;72(9):1575-80.PMID:23148305.
TenbaumSP,Ordóñez-MoránP,PuigI,etal.β-cateninconfersresistancetoPI3KandAKTinhibitorsandsubvertsFOXO3atopromotemetastasisincoloncancer.NatMed.2012Jun;18(6):892-901.PMID:22610277.
