Description
ZafirlukastiscommonlyrecognizedasaleukotrienereceptorantagoNISTwhichisusedinthetreatmentofasthma.ItisfoundtobeapotentinhibitorofVEGF-C/Nrp2.Researchontopicalusagesuggeststhatzafirlukastmayalsobeeffectiveinpreventingcapsularcontractureandreducingcapsuleformationofgelimplants,acomplicationarisingafterbreastimplantsurgery.
References
OdaS,FijiwaraR,KutsunoY,etal.TargetedscreenforhumanUDP-glucuronosyltransferasesinhibitorsandtheevaluationofpotentialdrug-druginteractionswithzafirlukast.DrugMetalDispos.2015Jun;43(6):812-818.PMID:25834030.
BandaruS,MarriVK,KaseraP,etal.Structurebasedvirtualscreeningofligandstoidentifycysteinylleukotrienereceptor1antagonist.Bioinformation.2014Oct30;10(10):652-657.PMID:25489175.
KangSH,ShinKC,KimWS,etal.Thepreventiveeffectoftopicalzafirlukastinstillationforperi-implantcapsuleformationinrabbits.ArchPlastSurg.2015Mar;42(2):179-185.PMID:25798389.