ZCL-278isaninhibitorofCdc42thatexhibitsanticanceractivity.ZCL-278inhibitsmicrospikeformationanddisruptsGM130-dockedGolgistructures.Additionally,thiscompoundshowssomeanti-metastaticpotential,inhibitingbranchingandactin-basedmotilityandmigrationofprostatecancercellsinvitro.
| CasNo. | 587841-73-4 |
|---|---|
| Purity | ≥98% |
| Formula | C21H19BrClN5O4S2 |
| FormulaWt. | 584.89 |
| IUPACName | 2-(4-bromo-2-chlorophenoxy)-N-[[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]carbamothioyl]acetamide |
| Synonym | ZCL278 |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | Z0944InfoSheetPDF |
|---|
FrieslandA,ZhaoY,ChenYH,etal.SmallmoleculetargetingCdc42-intersectininteractiondisruptsGolgiorganizationandsuppressescellmotility.ProcNatlAcadSciUSA.2013Jan22;110(4):1261-6.PMID:23284167.
