Description
Zoledronicacidisathirdgenerationbisphosphonatethatexhibitsanti-resorptive,anti-osteoporotic,anti-angiogenic,andanticancerchemotherapeuticactivities.Ingiantcelltumorbonestromalcells,zoledronicacidincreasesexpressionofCbfa-1,osteocalcin,andosterix,inducingapoptosisandosteogenicdifferentiation;italsoinhibitsboneresorptionandpreventsosteoporosisinanimalmodels.Inanimalmodelsofrenalcellcarcinoma,zoledronicaciddecreasesmeanvesseldensity.Inbreastcancercells,zoledronicacidreversestheepithelial-to-mesenchymaltransition(EMT)byinactivatingNF-κB,decreasingself-renewalandcellproliferation.Inothercellularmodels,zoledronicacidinhibitsfarnesyldiphosphatesynthase(FPPS),whichresultsinactivationofγδTcells.Acrossseveralbreastcancercelllines,zoledronicacidactivatescaspases3,8,and9anddecreasesexpressionofRasandMAPK,resultingintheinductionofcellcyclearrestorapoptosis.
References
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