Description
β-Caroteneisared-orangeterpenepigmentoriginallyfoundinvariousplantsandfruits;itisaprodrugforvitaminA.β-Caroteneexhibitsantioxidative,cytoprotective,anticancer,anti-inflammatory,anti-hyperlipidemic,andanti-obesityactivities.β-Caroteneisusedinresearchmodelstoquantifyantioxidativeactivity.Inbonemarrowcells,β-caroteneprotectsagainstrADIoactiveisotope-inducedDNAdamage.Inbreastcancercells,thiscompoundinducescellcyclearrestandapoptosis,decreasingcellularviABIlity.β-Carotenedecreasestotalcholesterol,VLDLandLDLlevels,suppressesexpressionofSREBP2andLDL-R,andincreasesexpressionofPPARαinvivo.Inotheranimalmodels,thiscompounddecreasesbodyfatandadipocytesizeandsuppressesTNF-α-inducedinflammation.
References
ABDel-MageedWM,BayoumiSA,SalamaAA,etal.AntioxidantlipoxygenaseinhibitorsfromtheleafextractsofSimmondsiachinensis.AsianPacJTropMed.2014Sep;7S1:S521-6.PMID:25312177.
BertiAP,DüsmanE,MariucciRG,etal.Antimutagenicandradioprotectiveactivitiesofbeta-caroteneagainsttheBIOLOGicaleffectsofiodine-131radiopharmaceuticalinWistarrats.GenetMolRes.2014Mar31;13(1):2248-58.PMID:24737473.
GloriaNF,SoaresN,BrandC,etal.Lycopeneandbeta-caroteneinducecell-cyclearrestandapoptosisinhumanbreastcancercelllines.AnticancerRes.2014Mar;34(3):1377-86.PMID:24596385.
SilvaLS,deMirandaAM,deBritoMagalhãesCL,etal.Dietsupplementationwithbeta-caroteneimprovestheserumlipidprofileinratsfedacholesterol-enricheddiet.JPhysiolBiochem.2013Dec;69(4):811-20.PMID:23645541.
DiTomoP,CanaliR,CiavardelliD,etal.β-CaroteneandlycopeneaffectendothelialresponsetoTNF-αreducingnitro-oxidativestressandinteractionwithmonocytes.MolNutrFoodRes.2012Feb;56(2):217-27.PMID:22162208.
AmengualJ,GourantonE,vanHeldenYG,etal.Beta-carotenereducesbodyadiposityofmiceviaBCMO1.PLoSOne.2011;6(6):e20644.PMID:21673813.
