Description
β-Naphthoflavone is an agonist at the aryl hydrocarbon receptor and an inducer of phase II enzymes. β-Naphthoflavone exhibits anticancer and chemopreventive activities but also displays tumor-promoting activity in other models. In animal models, β-naphthoflavone inhibits cigarette smoke-induced DNA damage and tumor development. In breast cancer cells, this compound induces G0/G1 phase cell cycle arrest, downregulates expression of cyclin D1, cyclin D3, and CDK4, upregulates expression of p21, inhibits PI3K/Akt signaling, and activates MAPK/ERK signaling.
References
Wang C, Xu CX, Bu Y, et al. Beta-naphthoflavone (DB06732) mediates estrogen receptor-positive breast cancer cell cycle arrest through AhR-dependent regulation of PI3K/AKT and MAPK/ERK signaling. Carcinogenesis. 2014 Mar;35(3):703-13. PMID: 24163404.
Tilton SC, Givan SA, Pereira CB, et al. Toxicogenomic profiling of the hepatic tumor promoters indole-3-carbinol, 17beta-estradiol and beta-naphthoflavone in rainbow trout. Toxicol Sci. 2006 Mar;90(1):61-72. PMID: 16192472.
Izzotti A, Bagnasco M, Cartiglia C, et al. Modulation of multigene expression and proteome profiles by chemopreventive agents. Mutat Res. 2005 Dec 11;591(1-2):212-23. PMID: 16083920.
