β-Rubromycin is a quinolone antibiotic that directly inhibits telomerase; it exhibits some antibacterial and antiviral activities. β-Rubromycin inhibits HIV-1 reverse transcriptase and also displays anticancer potential, decreasing the proliferation of cancer cells in vitro.
| Cas No. | 27267-70-5 |
|---|---|
| Purity | ≥98% |
| Formula | C27H20O12 |
| Formula Wt. | 536.44 |
| Chemical Name | Spiro(benzo(1,2-b:5,4-c')dipyran-2(3H),2'(3'H)-naphtho(1,2-b)furan)-7-carboxylic acid,4,4',5',9-tetrahydro -6',10-dihydroxy-7',9'-dimethoxy-4',5',9-trioxo-, methyl ester |
| IUPAC Name | methyl(2S)-8',10-dihydroxy-5',7'-dimethoxy-4',9,9'-trioxospiro[3,4-dihydropyrano[4,3-g]chromene-2,2'-3H-benzo[f][1]benzofuran]-7-carboxylate |
| Appearance | Dark Purple Solid |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | R8207 Info Sheet PDF |
|---|---|
| Brochures | Antivirals Booklet |
Mizushina Y, Takeuchi T, Sugawara F, et al. Anti-cancer targeting telomerase inhibitors: β-rubromycin and oleic acid. Mini Rev Med Chem. 2012 Oct;12(11):1135-43. PMID: 22876944.
Ueno T, Takahashi H, Oda M, et al. Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety. Biochemistry. 2000 May 23;39(20):5995-6002. PMID: 10821671.
Goldman ME, Salituro GS, Bowen JA, et al. Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site. Mol Pharmacol. 1990 Jul;38(1):20-5. PMID: 1695317.
