β-Rubromycinisaquinoloneantibioticthatdirectlyinhibitstelomerase;itexhibitssomeantibacterialandantiviralactivities.β-RubromycininhibitsHIV-1reversetranscriptaseandalsodisplaysanticancerpotential,decreasingtheproliferationofcancercellsinvitro.
| CasNo. | 27267-70-5 |
|---|---|
| Purity | ≥98% |
| Formula | C27H20O12 |
| FormulaWt. | 536.44 |
| ChemicalName | Spiro(benzo(1,2-b:5,4-c")dipyran-2(3H),2"(3"H)-naphtho(1,2-b)furan)-7-carboxylicacid,4,4",5",9-tetrahydro-6",10-dihydroxy-7",9"-dimethoxy-4",5",9-trioxo-,methylester |
| IUPACName | methyl(2S)-8",10-dihydroxy-5",7"-dimethoxy-4",9,9"-trioxospiro[3,4-dihydropyrano[4,3-g]chromene-2,2"-3H-benzo[f][1]benzofuran]-7-carboxylate |
| Appearance | DarkPurpleSolid |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | R8207InfoSheetPDF |
|---|---|
| Brochures | AntiviralsBooklet |
MizushinaY,TakeuchiT,SugawaraF,etal.Anti-cancertargetingtelomeraseinhibitors:β-rubromycinandoleicacid.MiniRevMedChem.2012Oct;12(11):1135-43.PMID:22876944.
UenoT,TakahashiH,OdaM,etal.Inhibitionofhumantelomerasebyrubromycins:implicationofspiroketalsystemofthecompoundsasanactivemoiety.Biochemistry.2000May23;39(20):5995-6002.PMID:10821671.
GoldmanME,SalituroGS,BowenJA,etal.Inhibitionofhumanimmunodeficiencyvirus-1reversetranscriptaseactivitybyrubromycins:competitiveinteractionatthetemplate.primersite.MolPharmacol.1990Jul;38(1):20-5.PMID:1695317.
