Description

Tocotrienolscontainanarenering,achromanolring,andanisoprenoidtail;alltocotrienolcompoundscontainamethylgrouponC8ofthearenering.δ-TocotrienolcontainsonlythemethylgroupatC8;allotheravailablesitesaresubstitutedwithhydrogenatoms.TocotrienolsaremembersofthevitaminEfamily,typicallyfoundinvegetableoils,nuts,andgrains.Tocotrienolsexhibitstrongantioxidativeactivityaswellasanti-angiogenic,anticancer,andanti-hyperlipidemicqualities.Ofallofthetocotrienols,δ-Tocotrienoldisplaysthestrongestanti-angiogenicandanticanceractivities.Tocopherols,commonsubstituentsofover-the-countervitaminEsupplements,interferewithtocotrienolactivityandshowweakerantioxidativeeffects.TocotrienolsexhibitsignificantrADIcalrecyclingABIlitiesincellularmodelsoflipidperoxidationandoxidativedamageandsuppressHMG-CoAreductaseactivity.Invitro,thesecompoundsinduceapoptosisthroughinhibitionofId1,EGFR,andNF-κB;theyalsoinhibitvesselformationandproliferationinaorticendothelialcells.