LKT/7,8-DIHYDROXYFLAVONE HYDRATE/D3329/100 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/7,8-DIHYDROXYFLAVONE HYDRATE/D3329/100 mg

LKT/7,8-DIHYDROXYFLAVONE HYDRATE/D3329/100 mg

商品编号： D3329-100mg

品牌： lktlabs

市场价： ¥1240.00

美元价： 744.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDD3329

CasNo.38183-03-8

Purity≥99%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

7,8-Dihydroxyflavone(DHF)isabrain-derivedneurotrophicfactor(BDNF)mimeticthatactivatesTrkBreceptors.DHFdisplaysneuromodulatory,neuroprotective,antipsychotic,anti-obesity,anticancer,antioxidative,anti-inflammatory,andantihypertensiveactivities.Inanimalmodelsoftraumaticbraininjury(TBI),DHFdecreasesbrainedema,neuronaldeath,andbraintissuedamageandimprovesfunctionaldeficits.Inanimalmodelsofschizophrenia,thiscompoundreversescognitivedeficitsandpromotessynapticplasticity.DHFalsobenefitsneurodegenerativediseasemodelssuchasParkinson’sdisease,Alzheimer’sdisease,andamyotrophiclateralsclerosis(ALS);inthesemodels,DHFdecreasesmotordeficitsandimprovescognitiveABIlities.DHFpreventstheinductionofdiet-inducedobesityinanimalmodelsandalsodecreasesADIposity,increasesenergyexpenditure,andimprovesinsulinsensitivityinalready-obeseanimals.Inoralsquamouscellcarcinomacells,thiscompounddecreasescellgrowthandinducesapoptosisbysuppressingSp1signaling.DHFalsodecreasesproductionofNOandPGE2andsuppressesexpressionofCOX-2,iNOS,TNF-α,andIL-1βinLPS-stimulatedmicroglia.Inothercellularmodels,DHFincreaseslevelsofHO-1andNrf2,protectingagainstH2O2-andUVlight-inducedoxidativedamage.DHFalsoincreaseseNOSexpressioninvitroanddecreasesbloodpressureinspontaneouslyhypertensiverats.

ProductInfo

CasNo.	38183-03-8
Purity	≥99%
Formula	C₁₅H₁₀O₄•xH₂O
FormulaWt.	254.24(anhy)
IUPACName	7,8-Dihydroxy-2-phenyl-4H-chromen-4-one
Appearance	Yellowpowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	D3329InfoSheetPDF

References

ChanCB,TseMC,LiuX,etal.ActivationofMuscularTrkBbyitsSmallMolecularAgoNIST7,8-DihydroxyflavoneSex-DependentlyRegulatesEnergyMetabolisminDiet-InducedObeseMice.2015Mar19;22(3):355-68.PMID:25754472.

SconceMD,ChurchillMJ,MooreC,etal.Interventionwith7,8-dihydroxyflavoneblocksfurtherstriatalterminallossandrestoresmotordeficitsinaprogressivemousemodelofParkinson"sdisease.Neuroscience.2015Apr2;290:454-71.PMID:25655214.

LeeRH,ShinJC,KimKH,etal.Apoptoticeffectsof7,8-dihydroxyflavoneinhumanoralsquamouscancercellsthroughsuppressionofSp1.OncolRep.2015Feb;33(2):631-8.PMID:25434704.

WuCH,HungTH,ChenCC,etal.Post-injurytreatmentwith7,8-dihydroxyflavone,aTrkBreceptoragonist,protectsagainstexperimentaltraumaticbraininjuryviaPI3K/Aktsignaling.PLoSOne.2014Nov21;9(11):e113397.PMID:25415296.

YangYJ,LiYK,WangW,etal.Small-moleculeTrkBagonist7,8-dihydroxyflavonereversescognitiveandsynapticplasticitydeficitsinaratmodelofschizophrenia.PharmacolBiochemBehav.2014Jul;122:30-6.PMID:24662915.

KorkmazOT,AytanN,CarrerasI,etal.7,8-Dihydroxyflavoneimprovesmotorperformanceandenhanceslowermotorneuronalsurvivalinamousemodelofamyotrophiclateralsclerosis.NeurosciLett.2014Apr30;566:286-91.PMID:24637017.

ParkHY,ParkC,HwangHJ,etal.7,8-Dihydroxyflavoneattenuatesthereleaseofpro-inflammatorymediatorsandcytokinesinlipopolysaccharide-stimulatedBV2microglialcellsthroughthesuppressionoftheNF-κBandMAPKsignalingpathways.IntJMolMed.2014Apr;33(4):1027-34.PMID:24535427.

RyuMJ,KangKA,PiaoMJ,etal.7,8-Dihydroxyflavoneprotectshumankeratinocytesagainstoxidativestress-inducedcelldamageviatheERKandPI3K/Akt-mediatedNrf2/HO-1signalingpathways.IntJMolMed.2014Apr;33(4):964-70.PMID:24503931.

CastelloNA,NguyenMH,TranJD,etal.7,8-Dihydroxyflavone,asmallmoleculeTrkBagonist,improvesspatialmemoryandincreasesthinspinedensityinamousemodelofAlzheimerdisease-likeneuronalloss.PLoSOne.2014Mar10;9(3):e91453.PMID:24614170.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂