ABT-737isaBH3mimeticthatactsasaninhibitorofBcl-2,Bxl-xl,andBcl-ω.ABT-737exhibitsanticancerchemotherapeuticandantithromboticactivities.ABT-737iscurrentlyinclinicaltrialsasonecomponentofacombinationtherapyinthetreatmentofvariouscancerssuchasacutemyelogenousleukemia(AML).ThiscompoundinhibitsgrowthofAMLcellsinvitroandincreasessurvivalratesandLifespaninanimalmodelsofAML.Invitro,ABT-737inducesmitochondrialmembranedepolarizationinplatelets,inducingapoptosisandclearance.
| CasNo. | 852808-04-9 |
|---|---|
| Purity | ≥98% |
| Formula | C42H45ClN6O5S2 |
| FormulaWt. | 813.43 |
| Synonym | ABT737 |
| Appearance | Yellowpowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A0778InfoSheetPDF |
|---|
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GyulkhandanyanAV,MutluA,AllenDJ,etal.BH3-mimeticABT-737inducesstrongmitochondrialmembranedepolarizationinplateletsbutonlyweaklystimulatesapoptoticmorphologicalchanges,plateletshrinkageandmicroparticleformation.ThrombRes.2014Jan;133(1):73-9.PMID:24268298.
BeurletS,OmidvarN,GorombeiP,etal.BCL-2inhibitionwithABT-737prolongssurvivalinanNRAS/BCL-2mousemodelofAMLbytargetingprimitiveLSKandProgenitorcells.Blood.2013Oct17;122(16):2864-76.PMID:23943652.
