LKT/AC-SDKP/S1343/10 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/AC-SDKP/S1343/10 mg

LKT/AC-SDKP/S1343/10 mg

商品编号： S1343-10mg

品牌： lktlabs

市场价： ¥5160.00

美元价： 3096.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDS1343

CasNo.120081-14-3

Purity≥95%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Ac-SKDPisapro-angiogenicpeptidedegradationproductofthymosinB4thatregulateshematopoiesisbyinhibitingproliferationofhematopoieticpluripotentstemcells(spleencolony-formingunits,orCFUs).Thispeptideexhibitscardioprotective,anti-inflammatory,andanti-fibroticactivities.Inanimalmodelsofchronicmyocardialinfarction,Ac-SDKPimprovesleftventricularfunction,increasesangiogenesis,anddecreasesinfarctsize.Inhypertensiverats,Ac-SDKPpreventsangiotensinII-inducedincreasesincollagensynthesisandcross-linkingaswellasexpressionofLOXandTGF-βandactivationofNF-κBandlymphocyticimmunecells.Inotheranimalmodels,thispeptidepreventsfibrosis,decreasingdepositionoffibronectinandcollagenanddecreasingthenumberofmyofibroblastsandmacrophages.Ac-SDKPalsoexhibitsnephroprotectiveactivity,inhibitingprogressionoflupusnephritisinanimalmodels;Ac-SDKPdecreasesproteinuria,infiltrationofinflammatoryTcellsandmacrophages,productionofTNF-α,activationofNF-κB,andphosphorylationofSmad2/3,resultinginimprovementsinrenalfunction.

ProductInfo

CasNo.	120081-14-3
Purity	≥95%
Formula	C₂₀H₃₃N₅O₉
FormulaWt.	487.51
IUPACName	(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carboxylicacid
Synonym	Goralatide
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

InfoSheet	S1343InfoSheetPDF

References

SongM,JangH,LeeJ,etal.RegenerationofchronicmyocardialinfarctionbyinjectablehydrogelscontainingstemcellhomingfactorSDF-1andangiogenicpeptideAc-SDKP.Biomaterials.2014Mar;35(8):2436-45.PMID:24378015.

GonzálezGE,RhalebNE,NakagawaP,etal.N-acetyl-seryl-aspartyl-lysyl-prolinereducescardiaccollagencross-linkingandinflammationinangiotensinII-inducedhypertensiverats.ClinSci(Lond).2014Jan1;126(1):85-94.PMID:23834332.

ZuoY,ChunB,PotthoffSA,etal.Thymosinβ4anditsdegradationproduct,Ac-SDKP,arenovelreparativefactorsinrenalfibrosis.KidneyInt.2013Dec;84(6):1166-75.PMID:23739235.

TanH,ZhaoJ,WangS,etal.Ac-SDKPamelioratestheprogressionoflupusnephritisinMRL/lprmice.IntImmunopharmacol.2012Dec;14(4):401-9.PMID:22922317.

LenfantM,Wdzieczak-BakalaJ,GuittetE,etal.Inhibitorofhematopoieticpluripotentstemcellproliferation:purificationanddeterminationofitsstructure.ProcNatlAcadSciUSA.1989Feb;86(3):779-82.PMID:2915977.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂