Aeruginosins are tetrapeptides found in cyanobacteria such as Microcystis aeruginosa. Like other cyanotoxins, aeruginosins inhibit serine proteases and protein phosphatases (PPs). In endothelial cells, aeruginosins decrease levels of IL-8 and ICAM-1 and inhibit NF-κB activity. Aeruginosins may also bind thrombin and exhibit antithrombotic activity.
| Purity | ≥95% |
|---|---|
| Formula | C32H43ClN6O9S |
| Formula Wt. | 723.24 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Blue Ice |
| MSDS | A1890 MSDS PDF |
|---|---|
| Info Sheet | A1890 Info Sheet PDF |
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Silva-Stenico ME, Silva CS, Lorenzi AS, et al. Non-ribosomal peptides produced by Brazilian cyanobacterial isolates with antimicrobial activity. Microbiol Res. 2011 Mar 20;166(3):161-75. PMID: 20630723.
Wang G, Goyal N. Aeruginosin analogs and other compounds with rigid bicyclic structure as potential antithrombotic agents. Cardiovasc Hematol Agents Med Chem. 2009 Apr;7(2):147-65. PMID: 19355876.
Radau G, Gebel J, Rauh D. New cyanopeptide-derived low molecular weight thrombin inhibitors. Arch Pharm (Weinheim). 2003 Aug;336(8):372-80. PMID: 14502757.
