LKT/半富马酸阿利吉仑/A4534/25 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/半富马酸阿利吉仑/A4534/25 mg

LKT/半富马酸阿利吉仑/A4534/25 mg

商品编号： A4534-25mg

品牌： lktlabs

市场价： ¥1340.00

美元价： 804.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDA4534

CasNo.173334-58-2

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Aliskirenisadirectrenininhibitorthatexhibitsantihypertensive,antithrombotic,andanti-angiogenicactivities.AliskirenbindstotheS3bpbindingsiteofrenin,inhibitingitsABIlitytocleaveangiotensininintoangiotensinI,thereforepreventingtheformationofangiotensinIIandresultingcontractionofarterialsmoothmuscle.Thiscompoundisavasodilator,decreasingplasmavolumeandbloodpressureinvivo.Inanimalmodelsoflupusnephritis,aliskirenattenuatedproteinuriabydecreasinginflammatorycytokinelevelsandglomerularinflammation.Additionally,inseparateanimalstudies,aliskirendecreasesVEGFlevels,improvesinsulinresistance,andpreventsdevelopmentofvenousthrombosis.

ProductInfo

CasNo.	173334-58-2
Purity	≥98%
Formula	(C₃₀H₅₃N₃O₆)₂•C₄H₄O₄
FormulaWt.	1219.59
ChemicalName	(2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-(propan-2-yl)nonanamidehemifumarate
IUPACName	(2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide;(E)-but-2-enedioicacid
Solubility	Solubleinwater(≥122mg/mL),ethanol≥122mg/mL),andDMSO(≥122mg/mL).
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

MSDS	A4534MSDSPDF
InfoSheet	A4534InfoSheetPDF

References

YenTH,YangHY,YehYH,etal.Aliskirenattenuatesproteinuriainmicewithlupusnephritisbyabloodpressure-independentmechanism.Lupus.2013Feb;22(2):180-9.PMID:23257405.

HermanowiczJM,HermanowiczA,BuczkoP,etal.Aliskireninhibitsexperimentalvenousthrombosisintwo-kidneyone-cliphypertensiverats.ThrombRes.2013Jan;131(1):e39-44.PMID:23174623.

GandhiS,SrinivasanB,AkarteAS.AliskirenimprovesinsulinresistanceandamelioratesdiabeticrenalvascularcomplicationsinSTZ-induceddiabeticrats.JReninAngiotensinAldosteroneSyst.2013Mar;14(1):3-13.PMID:22791702.

KühnastS,vanderHoornJW,vandenHoekAM,etal.AliskireninhibitsatherosclerosisdevelopmentandimprovesplaquestabilityinAPOE*3Leiden.CETPtransgenicmicewithorwithouttreatmentwithatorvastatin.JHypertens.2012Jan;30(1):107-16.PMID:22134386.

BuczkoW,HermanowiczJM.Pharmacokineticsandpharmacodynamicsofaliskiren,anoraldirectrenininhibitor.PharmacolRep.2008Sep-Oct;60(5):623-31.PMID:19066408.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂