Amilorideisapotassium-sparingdiureticthatexhibitsantihypertensiveandantiviralactivities.AmilorideinhibitsepithelialNa+channels(ENaCs),acid-sensingionchannels,andNa+/H+antiporters.AmiloridepreventsNa+reabsorptioninthekidney,increasingexcretionofNa+andwater;itisclinicallyusedtotreathypertensionandcongestiveheartfailure(CHF).Invitro,amilorideinhibitsreplicationofCoxsackievirusB3andpoliovirustype1.
| CasNo. | 17440-83-4 |
|---|---|
| Purity | ≥98% |
| Formula | C6H8ClN7O•HCl•2H2O |
| FormulaWt. | 302.12 |
| ChemicalName | 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazine-carboxamidehydrochloride |
| IUPACName | 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;dihydrate;hydrochloride |
| Synonym | N-Amidino-3,5-diamino-6-chloropyrazinecarboxamidemonohydrochloride;Amiprazidine |
| MeltingPoint | 285-288°C |
| Solubility | Solubleinwater. |
| Appearance | Lightyellowcrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A5133InfoSheetPDF |
|---|
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YuX,HuY,YuS.Effectsofacidonvagalnociceptiveafferentsubtypesinguineapigesophagus.AmJPhysiolGastrointestLiverPhysiol.2014Aug15;307(4):G471-8.PMID:24994852.
PaarM,PavenstädtH,Kusche-VihrogK,etal.Endothelialsodiumchannelstriggerendothelialsaltsensitivitywithaging.Hypertension.2014Aug;64(2):391-6.PMID:24866143.
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