Amiloride is a potassium-sparing diuretic that exhibits antihypertensive and antiviral activities. Amiloride inhibits epithelial Na+ channels (ENaCs), acid-sensing ion channels, and Na+/H+ antiporters. Amiloride prevents Na+ reabsorption in the kidney, increasing excretion of Na+ and water; it is clinically used to treat hypertension and congestive heart failure (CHF). In vitro, amiloride inhibits replication of Coxsackievirus B3 and poliovirus type 1.
| Cas No. | 17440-83-4 |
|---|---|
| Purity | ≥98% |
| Formula | C6H8ClN7O • HCl • 2H2O |
| Formula Wt. | 302.12 |
| Chemical Name | 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazine-carboxamide hydrochloride |
| IUPAC Name | 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;dihydrate;hydrochloride |
| Synonym | N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide monohydrochloride; Amiprazidine |
| Melting Point | 285-288°C |
| Solubility | Soluble in water. |
| Appearance | Light yellow crystalline powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | A5133 Info Sheet PDF |
|---|
Ogram SA, Boone CD, McKenna R, et al. Amiloride inhibits the initiation of Coxsackievirus and poliovirus RNA replication by inhibiting VPg uridylylation. Virology. 2014 Sep;464-465:87-97. PMID: 25058507.
Yu X, Hu Y, Yu S. Effects of acid on vagal nociceptive afferent subtypes in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2014 Aug 15;307(4):G471-8. PMID: 24994852.
Paar M, Pavenstädt H, Kusche-Vihrog K, et al. Endothelial sodium channels trigger endothelial salt sensitivity with aging. Hypertension. 2014 Aug;64(2):391-6. PMID: 24866143.
Bhagatwala J, Harris RA, Parikh SJ, et al. Epithelial sodium channel inhibition by amiloride on blood pressure and cardiovascular disease risk in young prehypertensives. J Clin Hypertens (Greenwich). 2014 Jan;16(1):47-53. PMID: 24410943.
