Aminophyllineisanon-selectiveadenosinereceptorantagoNISTandphosphodiesterase(PDE)inhibitor.Aminophyllineexhibitsvasodilatoryandanti-inflammatoryactivityandisoccasionallyclinicallyusedtotreatchronicobstructivepulmonarydisorder(COPD).Inanimalmodelsofallergen-inducedlunginflammation,aminophyllinedecreaseslevelsofIL-5,IL-8,andeosinophils.
| CasNo. | 317-34-0 |
|---|---|
| Purity | ≥98% |
| Formula | C16H24N10O4 |
| FormulaWt. | 420.43 |
| ChemicalName | 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dionecompdwith1,2-ethanediamine(2:1) |
| IUPACName | 1,3-dimethyl-7H-purine-2,6-dione;ethane-1,2-diamine |
| Synonym | Aminophylline;Afonilum;Cardophylin;Pecram;Phyllotemp;Tefamin |
| MeltingPoint | 269-270°C |
| Solubility | Solubleinwater.Insolubleinalcoholandether. |
| Appearance | Awhiteorslightlyyellowishpowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | A5134MSDSPDF |
|---|---|
| InfoSheet | A5134InfoSheetPDF |
NickelsTJ,SchwartzAD,BlevinsDE,etal.EffectoftheophyllineandaminophyllineontransmitterreleaseatthemammalianneuromuscularjunctionisnotmediatedbycAMP.ClinExpPharmacolPhysiol.2006May-Jun;33(5-6):465-70.PMID:16700879.
DanahayH,BroadleyKJ,McCabePJ,etal.Thepotentialrolesofcytokines,IL-5andIL-8,andplasmacortisolintheanti-inflammatoryactionsofphosphodiesteraseinhibitorsinsensitizedguinea-pigairways.PulmPharmacolTher.1997Oct-Dec;10(5-6):277-85.PMID:9778491.
