Aminophyllineisanon-selectiveadenosinereceptorantagoNISTandphosphodiesterase(PDE)inhibitor.Aminophyllineexhibitsvasodilatoryandanti-inflammatoryactivityandisoccasionallyclinicallyusedtotreatchronicobstructivepulmonarydisorder(COPD).Inanimalmodelsofallergen-inducedlunginflammation,aminophyllinedecreaseslevelsofIL-5,IL-8,andeosinophils.
| Purity | ≥98% |
|---|---|
| Formula | C16H24N10O4•2H2O |
| FormulaWt. | 456.47 |
| ChemicalName | 3,7-Dihydro-1,3-dimetheyl-1H-purine-2,6-dione |
| IUPACName | 1,3-dimethyl-7H-purine-2,6-dione;ethane-1,2-diamine;dihydrate |
| Synonym | Theophyllinecompoundwithethylenediamine |
| Solubility | Solubleinwater(1g/5mL).Insolubleinalcoholandether. |
| Appearance | Whitetoyellowishpowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A5135InfoSheetPDF |
|---|
NickelsTJ,SchwartzAD,BlevinsDE,etal.EffectoftheophyllineandaminophyllineontransmitterreleaseatthemammalianneuromuscularjunctionisnotmediatedbycAMP.ClinExpPharmacolPhysiol.2006May-Jun;33(5-6):465-70.PMID:16700879.
DanahayH,BroadleyKJ,McCabePJ,etal.Thepotentialrolesofcytokines,IL-5andIL-8,andplasmacortisolintheanti-inflammatoryactionsofphosphodiesteraseinhibitorsinsensitizedguinea-pigairways.PulmPharmacolTher.1997Oct-Dec;10(5-6):277-85.PMID:9778491.
