AmiodaroneisaclassIIIanti-arrhythmicthatinhibitsNa+channels,voltage-gatedCa2+channels,voltage-gatedK+channels,andα/β-adrenergicreceptors.Amiodaroneprolongsthedurationoftheactionpotential,increasingthelengthoftherefractoryperiod;itisclinicallyusedtotreatventricularfibrillationandventriculartachycardia.Amiodaronealsoexhibitsantiviralactivity,inhibitingcellentrybyfilovirus,guanaritovirus,andhepatitisC.Additionally,thiscompoundactsasafunctionalinhibitorofacidsphingomyelinase(FIASMA).
| CasNo. | 19774-82-4 |
|---|---|
| Purity | ≥98% |
| Formula | C25H29I2NO3•HCl |
| FormulaWt. | 681.78 |
| ChemicalName | (2-Butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanonehydrochloride |
| IUPACName | (2-butyl-1-benzofuran-3-yl)-[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone;hydrochloride |
| Synonym | Amiodar;Ancaron;Cordarone;Ortacrone;Tachydaron;Trangorex |
| MeltingPoint | 156°C |
| Solubility | Solubleinmethanol,chloroform,andmethylenechloride.Slightlysolubleinacetoneanddioxane.Sparinglysolubleinisopropanol. |
| Appearance | WhiteoralmostwhiteCrystalPowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | A5037MSDSPDF |
|---|---|
| InfoSheet | A5037InfoSheetPDF |
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GehringG,RohrmannK,AtenchongN,etal.Theclinicallyapproveddrugsamiodarone,dronedaroneandverapamilinhibitfiloviruscellentry.JAntimicrobChemother.2014Apr7.[Epubaheadofprint].PMID:24710028.
ChengYL,LanKH,LeeWP,etal.AmiodaroneinhibitstheentryandassemblystepsofhepatitisCviruslifecycle.ClinSci(Lond).2013Nov;125(9):439-48.PMID:23659500.
