AmlodipineisadihydropyridineL-typeCa2+channelblockerthatexhibitsantihypertensive,anti-anginal,andvasodilatoryactivities.Amlodipineisclinicallyusedtotreathypertensionandanginaasitinducesrelaxationofarterialsmoothmuscles,decreasesbloodpressure,andincreasesbloodflowtotheheart.Amlodipinealsoinhibitsacidsphingomyelinase(FIASMA),whichisinvolvedinprogrammedcelldeath.Additionally,thiscompoundimprovessmoothmusclehypertrophyandcollagendeposition,preventingarterialremodelinginhypertensiverats.
| CasNo. | 88150-42-9 |
|---|---|
| Purity | ≥98% |
| Formula | C20H25ClN2O5 |
| FormulaWt. | 408.88 |
| ChemicalName | 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylicacid3-ethyl5-methylester |
| IUPACName | 3-O-ethyl5-O-methyl2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| Synonym | UK-48340 |
| MeltingPoint | 134-136°C |
| Solubility | Solubleinmethanol,ethanol(82mg/mL)choroformandDMSO(82mg/mL). |
| Appearance | AlmostWhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | A5045MSDSPDF |
|---|---|
| InfoSheet | A5045InfoSheetPDF |
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