Amrinoneisapyridinephosphodiesterase3(PDE3)inhibitorthatisclinicallyusedtotreatcongestiveheartfailure(CHF).AmrinonemaybeadmiNISTeredduringcardiopulmonarybypasssurgery.Amrinoneexhibitspositiveinotropicactivity,inducingvasodilationandincreasingcardiaccontractilitythroughalterationsincAMPandCa2+signaling.
| CasNo. | 60719-84-8 |
|---|---|
| Purity | ≥98% |
| Formula | C10H9N3O |
| FormulaWt. | 187.20 |
| ChemicalName | 5-Amino-(3,4"-bipyridin)-6(1H)-one |
| IUPACName | 3-amino-5-pyridin-4-yl-1H-pyridin-2-one |
| Synonym | Cartonic;Inocor;Vesistol;Wincoram |
| MeltingPoint | 294-297°C(dec.) |
| Solubility | Insolubleinwater.Slightlysolubleinhotaceticacidanddimethylformamide.Solubleindiluteinorganicacids. |
| Appearance | YellowtolightyellowcrystallinePowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | A5170MSDSPDF |
|---|---|
| InfoSheet | A5170InfoSheetPDF |
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vanderZyppA,RechtmanM,MajewskiH.Theroleofcyclicnucleotidesandcalciumintherelaxationproducedbyamrinoneinrataorta.GenPharmacol.2000Apr;34(4):245-53.PMID:11282218.
HamadaY,KawachiK,YamamotoT,etal.EffectsofsingleadministrationofaphosphodiesteraseIIIinhibitorduringcardiopulmonarybypass:comparisonofmilrinoneandamrinone.JpnCircJ.1999Aug;63(8):605-9.PMID:10478810.
