Description
ArtemisininisasesquiterpenelactoneoriginallyfoundinArtemisia(wormwood);itisclinicallyusedtotreatmalaria.Artemisininexhibitsanti-parasitic,antimalarial,cardioprotective,anticancer,andanti-inflammatoryactivities.ThiscompoundinhibitsgrowthofPlasmodium.Inanimalmodelsofmyocardialinfarction,artemisinindecreasesventricularfibrillationthresholdandlevelsofTNF-αandincreasesexpressionofconnexin43.Inmacrophages,thiscompoundinhibitsIL-6release.Artemisininalsoinhibitsgrowthofneuroblastomacells,increasingactivationofAMPKanddecreasingsignalingbymTOR.
References
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