LKT/ASIATIC ACID, 95%/A7332/500 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/ASIATIC ACID, 95%/A7332/500 mg

LKT/ASIATIC ACID, 95%/A7332/500 mg

商品编号： A7332-500mg

品牌： lktlabs

市场价： ¥3600.00

美元价： 2160.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDA7332

CasNo.464-92-6

Purity≥95%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

AsiaticacidisatriterpeneaglyconeoriginallyfoundinCentella;itexhibitscardioprotective,hepatoprotective,anti-inflammatory,antioxidative,antihypertensive,anticancer,anti-fibrotic,andanti-osteoporoticactivities.Invitroandinvivo,asiaticacidinhibitsTGF-β1-inducedandoverload-inducedcardiachypertrophy,decreasingproductionofTGF-β1andactivationofNF-κB,ERK1/2,andp38MAPK.Inhighfatdiet-fedrats,asiaticaciddecreasesexpressionofNF-κB,p38MAPK,IL-1β,ROS,IL-6,andTNF-αandincreasesactivityofglutathioneperoxidaseandcatalase,preventinghepaticsteatosis.Additionally,asiaticacidinhibitsL-NAME-inducedhypertension,increasinglevelsofNOandimprovingvascularfunction.Inmultiplemyelomacells,thiscompoundinducesG2/Mphasecellcyclearrest,decreasesexpressionofFAK,andinhibitscellproliferation.AsiaticacidinhibitsADIpogenesis,suppressesactivationofG3PDH,andmodulatesdifferentiationinbonemarrowstromalcells.Inanimalmodelsoffibrosis,thiscompounddecreasestubularinjuryandfibroblastactivationbysuppressingactivationofSmad2/3,regulatingPPARγactivation,anddecreasinglevelsofα-SMAandTGF-β1.

ProductInfo

CasNo.	464-92-6
Purity	≥95%
Formula	C₃₀H₄₈O₅
FormulaWt.	488.70
IUPACName	(1S,2R,4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylicacid
Synonym	NSC166063
MeltingPoint	325-330°C
Solubility	Ethanol10mg/mL,DMSO20mg/mL,DMF20mg/mL
Appearance	WhiteCrystalPowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	A7332MSDSPDF
InfoSheet	A7332InfoSheetPDF

References

SiL,XuJ,YiC,etal.Asiaticacidattenuatescardiachypertrophybyblockingtransforminggrowthfactor-β1-mediatedhypertrophicsignalinginvitroandinvivo.IntJMolMed.2014Aug;34(2):499-506.PMID:24827470.

YanSL,YangHT,LeeYJ,etal.Asiaticacidameliorateshepaticlipidaccumulationandinsulinresistanceinmiceconsumingahigh-fatdiet.JAgricFoodChem.2014May21;62(20):4625-31.PMID:24779966.

BunbuphaS,PakdeechoteP,KukongviriyapanU,etal.AsiaticAcidReducesBloodPressurebyEnhancingNitricOxideBioavailABIlitywithModulationofeNOSandp47phoxExpressioninl-NAME-inducedHypertensiveRats.PhytotherRes.2014Apr11.[Epubaheadofprint].PMID:24723332.

LiZW,PiaoCD,SunHH,etal.Asiaticacidinhibitsadipogenicdifferentiationofbonemarrowstromalcells.CellBiochemBiophys.2014Mar;68(2):437-42.PMID:23934183.

ZhangJ,AiL,LvT,etal.Asiaticacid,atriterpene,inhibitscellproliferationthroughregulatingtheexpressionoffocaladhesionkinaseinmultiplemyelomacells.OncolLett.2013Dec;6(6):1762-1766.PMID:24260073.

BianD,ZhangJ,WuX,etal.AsiaticacidisolatedfromCentellaasiaticainhibitsTGF-β1-inducedcollagenexpressioninhumankeloidfibroblastsviaPPAR-γactivation.IntJBiolSci.2013Oct25;9(10):1032-42.PMID:24250248.

XuC,WangW,XuM,etal.Asiaticacidamelioratestubulointerstitialfibrosisinmicewithureteralobstruction.ExpTherMed.2013Sep;6(3):731-736.PMID:24137256.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂