LKT/ASTRAGALOSIDE IV/A7578/10 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/ASTRAGALOSIDE IV/A7578/10 mg

LKT/ASTRAGALOSIDE IV/A7578/10 mg

商品编号： A7578-10mg

品牌： lktlabs

市场价： ¥3680.00

美元价： 2208.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDA7578

CasNo.83207-58-3

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

AstragalosideIVisanactivecompoundfoundinAstragalusmembranaceusthatexhibitscardioprotective,antioxidative,andpro-angiogenicactivities.AstragalosideIVpreventsLPS-inducedincreasesinCa2+,activationofCaNandGATA-4,andnuclearfactorofactivatedTcells3(NFAT3)translocation,inhibitingcardiachypertrophy.Additionally,astragalosideIVdecreasesexpressionofmatrixmetalloproteinase9(MMP-9)andpreventsischemia/reperfusion-inducedmyocardialinfarctionandmyocardialapoptosisinanimalmodels.Inotheranimals,astragalosideIVpreventedincreasesinROS,pro-inflammatorycytokines,anddownregulationofsuperoxidedismutase(SOD),glutathione,andtauphosphorylationinducedbyexperimentalautoimmuneencephalitis(EAE);thiscompoundalsopreventsrelateddecreasesintheBcl-2/BaxratioandchangesinTcelldifferentiationandmigration.Inendothelialcells,astragalosideIVactivatesJAK/STATandERK1/2signalingandupregulatesproductionofeNOSandNO,promotingtube/vesselformation.

ProductInfo

CasNo.	83207-58-3
Purity	≥98%
Formula	C₄₁H₆₈O₁₄
FormulaWt.	784.97
MeltingPoint	295-296°C
Solubility	SolubleinDMSO(10mg/mL),ethanol.Insolubleinwater.
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	A7578InfoSheetPDF

References

LuM,WangH,WangJ,etal.AstragalosideIVProtectsagainstCardiacHypertrophyviaInhibitingtheCa2+/CaNSignalingPathway.PlantaMed.2013Dec11.[Epubaheadofprint].PMID:24338553.

WangSG,XuY,ChenJD,etal.AstragalosideIVstimulatesangiogenesisandincreasesnitricoxideaccumulationviaJAK2/STAT3andERK1/2pathway.Molecules.2013Oct16;18(10):12809-19.PMID:24135938.

HeY,DuM,GaoY,etal.AstragalosideIVattenuatesexperimentalautoimmuneencephalomyelitisofmicebycounteractingoxidativestressatmultiplelevels.PLoSOne.2013Oct4;8(10):e76495.PMID:24124567.

LiM,MaRN,LiLH,etal.AstragalosideIVreducescerebraledemapost-ischemia/reperfusioncorrelatingthesuppressionofMMP-9andAQP4.EurJPharmacol.2013Sep5;715(1-3):189-95.PMID:23747593.

TuL,PanCS,WeiXH,etal.AstragalosideIVprotectsheartfromischemiaandreperfusioninjuryviaenergyregulationmechanism.Microcirculation.2013Jun28.[Epubaheadofprint].PMID:23809007.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂