Description
AtropineisatropanealkaloidfoundinplantsintheSolanaceaefamily.Atropineisananticholinergiccompoundthatalsoexhibitsanalgesicandantinociceptiveactivities.Atropineisacompetitiveinhibitorofmuscarinicacetylcholinereceptors(mAChRs)thatiscommonlyusedforophthalmictreatmentssuchasinitiatingmydriasis.Atropinedisplayscardiostimulatory/positiveinotropicactivityaswell,increasingheartratebyinhibitingvagalnerveactivity.Inanimalmodelsofthermalpain,atropineexhibitsanalgesicactivity;inotheranimalmodels,atropineinhibitshistamine-inducedincreasesinthromboxaneA2(TxA2)levels.