AZD-6482isaninhibitorofp110βPI3K.AZD-6482inhibitsinsulin-inducedADIpocyteglucoseuptakeinvitroandincreasesglucosehomeostasisinvivo.Additionally,AZD-6482exhibitsantithromboticactivitywithoutincreasingbleedingtimeorbloodlossinotheranimalmodels.
| CasNo. | 1173900-33-8 |
|---|---|
| Purity | ≥98% |
| Formula | C22H24N4O4 |
| FormulaWt. | 408.45 |
| IUPACName | 2-[[(1R)-1-(7-methyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoicacid |
| Appearance | Off-whitePowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A9712InfoSheetPDF |
|---|
WeigeltB,WarnePH,LambrosMB,etal.PI3Kpathwaydependenciesinendometrioidendometrialcancercelllines.ClinCancerRes.2013Jul1;19(13):3533-44.PMID:23674493.
NylanderS,KullB,BjörkmanJA,etal.Humantargetvalidationofphosphoinositide3-kinase(PI3K)β:effectsonplateletsandinsulinsensitivity,usingAZD6482anovelPI3Kβinhibitor.JThrombHaemost.2012Oct;10(10):2127-36.PMID:22906130.
