AzelnidipineisadihydropyridineL-typeCa2+channelblockerthatexhibitsantihypertensive,anti-atherosclerotic,andanti-inflammatoryactivities.Clinically,azelnidipinedecreasesbloodpressure;italsodecreasesinflammatorycytokinelevelsandcarotidintima-mediathickness.Additionally,thiscompoundpreservesinsulinsignalingandglucoseuptakeinanimalmodelsofoxidativestress.
| CasNo. | 123524-52-7 |
|---|---|
| Purity | ≥98% |
| Formula | C33H34N4O6 |
| FormulaWt. | 582.66 |
| IUPACName | 3-[1-(Diphenylmethyl)-3-azetidinyl]5-isopropyl2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A9617InfoSheetPDF |
|---|
TawaramotoK,KanetoH,HashiramotoM,etal.Azelnidipine,butnotamlodipine,reducesurinaryalbuminexcretionandcarotidatherosclerosisinsubjectswithtype2diabetes:bloodpressurecontrolwitholmesartanandazelnidipineinType2diabetes(BOAT2study).DiabetolMetabSyndr.2015Sep17;7:80.PMID:26388951.
TatsumiF,KanetoH,HashiramotoM,etal.Anti-hypertensiveazelnidipinepreservesinsulinsignalingandglucoseuptakeagainstoxidativestressin3T3-L1ADIpocytes.EndocrJ.2015;62(8):741-7.PMID:26073866.
ChenBL,ZhangYZ,LuoJQ,etal.ClinicaluseofazelnidipineinthetreatmentofhypertensioninChinesepatients.TherClinRiskManag.2015Feb24;11:309-18.PMID:25750535.
