LKT/BENIDIPINE HYDROCHLORIDE/B1752/10 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/BENIDIPINE HYDROCHLORIDE/B1752/10 mg

LKT/BENIDIPINE HYDROCHLORIDE/B1752/10 mg

商品编号： B1752-10mg

品牌： lktlabs

市场价： ¥760.00

美元价： 456.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDB1752

CasNo.91599-74-5

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Benidipineisalong-lastingdihydropyridinecalciumchannelblocker.ItsantihypertensiveactivityinvolvestheinhibitionofCa(2+)influxthroughL-typevoltagedependentcalciumchannelsandtheABIlitytorestoreendothelialfunction.ItpreventslysoPC-inducedcaspase-3activationthroughstimulationofNOreleasetherebyexertsitsanti-apoptosisactiononendothelialcells.BenidipineincreasesthemaximalactivityofERK1/2buthasnosignificanteffectonp38MARK,decreasesmitochondrialcytochromecrelease,andreducescaspase-9activation.BenidipinewasshowntohaveantioxidanteffectinreducinghydroxylrADIcalsformationandPKC-dependentNOproduction.Itinhibits[3H]thymidineincorporationintovascularsmoothmusclecells(VSMCs),anindicationofitsanti-proliferativeeffectswhichmaybeusefulforthetreatmentofrestenosisfollowingangioplastyandatherosclerosisdamages.

ProductInfo

CasNo.	91599-74-5
Purity	≥98%
Formula	C₂₈H₃₁N₃O₆・HCl
FormulaWt.	542.03
IUPACName	(3R)-1-Benzyl-3-piperidinylmethyl(4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylatehydrochloride(1:1)
Synonym	KW-3049

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	B1752InfoSheetPDF

References

MatsubaraM,YaoK,HasegawaK.Benidipine,adihydropyridine-calciumchannelblocker,inhibits
lysophosphatidylcholine-inducedendothelialinjuryviastimulationofnitricoxiderelease.PharmacolRes.2006Jan;53(1):35-43.PMID:16172001.

WangN,MinatoguchiS,ChenXH,etal.
BenidipinereducesmyocardialinfarctsizeinvolvingreductionofhydroxylradicalsandproductionofproteinkinaseC-dependentnitricoxideinrabbits.JCardiovascPharmacol.2004Jun;43(6):747-57.PMID:15167267.

IdeS,KondohM,SatohH,KarasawaA.Anti-proliferativeeffectsofbenidipinehydrochlorideinporcinecultured
vascularsmoothmusclecellsandinratssubjectedtoballooncatheterinducedendothelialdenudation.BiolPharmBull.1994May;17(5):627-31.PMID:7920421.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂