LKT/BENZYL ISOTHIOCYANATE/B1653/10 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/BENZYL ISOTHIOCYANATE/B1653/10 g

LKT/BENZYL ISOTHIOCYANATE/B1653/10 g

商品编号： B1653-10g

品牌： lktlabs

市场价： ¥1620.00

美元价： 972.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDB1653

CasNo.622-78-6

Purity≥97%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Benzylisothiocyanate(BITC)isanisothiocyanateoriginallyfoundincruciferousvegetablesthatexhibitsimmunomodulatory,anti-parasitic,antibiotic,antioxidative,anti-atherosclerotic,anti-angiogenic,anti-metastatic,anticancerchemotherapeutic,andchemopreventiveactivities.BITCinhibitsIL-13expressioninbasophils.BITCinducesphaseIIenzymes,increasinglevelsofhemeoxygenase1(HO-1),glutathione,andglutamatecysteineligase;italsodecreaseslevelsofROS,activationofNF-κB,adhesionofmonocytes,andexpressionofICAM-1,VCAM-1,andE-selectin.ThiscompoundinhibitsgrowthofTrypanosomaanddisplaysantibacterialefficacyagainstCampylobacterbydisruptingmetabolicprocesses.Invitroandinvivo,BITCdecreaseshighfatdiet-inducedtumorgrowthandmultiplicity,alsoinhibitingmacrophagemigrationandlipiddropletaccumulation.Thiscompoundinhibitssquamouscellcarcinomacellinvasionandmigrationandinducesapoptosisandautophagyinprostatecancercells.Invariousanimalmodels,BITCinhibitsdevelopmentofmammaryglandtumorsanddecreasesactivationofSTAT3andsecretionofVEGF,MMP-2,andHIF-1α.

ProductInfo

CasNo.	622-78-6
Purity	≥97%
Formula	C₈H₇NS
FormulaWt.	149.22
ChemicalName	Benzene,(isothiocyanatomethyl)-
IUPACName	isothiocyanatomethylbenzene
Synonym	Isothiocyanicacidbenzylester;2-Bromo-4-trifluoro-methyl-6-nitrophenyl-isothiocyanate
MeltingPoint	41°C
Solubility	SolubleinDMSO,ethanol,orchloroform.
Appearance	ClearLightYellowLiquid

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

MSDS	B1653MSDSPDF
InfoSheet	B1653InfoSheetPDF

References

TangY,AbeN,YoshimotoM,etal.BenzylisothiocyanateinhibitsIL-13expressioninhumanbasophilicKU812cells.BiosciBiotechnolBiochem.2014Sep25:1-5.PMID:25253661.

KimM,ChoHJ,KwonGT,etal.Benzylisothiocyanatesuppresseshigh-fatdiet-stimulatedmammarytumorprogressionviathealterationoftumormicroenvironmentsinobesity-resistantBALB/cmice.MolCarcinog.2014Apr11.[Epubaheadofprint].PMID:24729546.

SteverdingD,MichaelsS,ReadKD.Invitroandinvivostudiesoftrypanocidalactivityofdietaryisothiocyanates.PlantaMed.2014Feb;80(2-3):183-6.PMID:24452460.

DufourV,StahlM,RosenfeldE,etal.InsightsintothemodeofactionofbenzylisothiocyanateonCampylobacterjejuni.ApplEnvironMicrobiol.2013Nov;79(22):6958-68.PMID:24014524.

HuangCS,LinAH,LiuCT,etal.IsothiocyanatesprotectagainstoxidizedLDL-inducedendothelialdysfunctionbyupregulatingNrf2-dependentantioxidationandsuppressingNFκBactivation.MolNutrFoodRes.2013Nov;57(11):1918-30.PMID:23836589.

LinJF,TsaiTF,LiaoPC,etal.BenzylisothiocyanateinducesprotectiveautophagyinhumanprostatecancercellsviainhibitionofmTORsignaling.Carcinogenesis.2013Feb;34(2):406-14.PMID:23172666.

BoreddySR,SahuRP,SrivastavaSK.BenzylisothiocyanatesuppressespancreatictumorangiogenesisandinvasionbyinhibitingHIF-α/VEGF/Rho-GTPases:pivotalroleofSTAT-3.PLoSOne.2011;6(10):e25799.PMID:22016776.

WarinR,ChambersWH,PotterDM,etal.PreventionofmammarycarcinogenesisinMMTV-neumicebycruciferousvegetableconstituentbenzylisothiocyanate.CancerRes.2009Dec15;69(24):9473-80.PMID:19934325.

KimSH,NagalingamA,SaxenaNK,etal.Benzylisothiocyanateinhibitsoncogenicactionsofleptininhumanbreastcancercellsbysuppressingactivationofsignaltransducerandactivatoroftranscription3.Carcinogenesis.2011Mar;32(3):359-367.PMID:21163886.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂