Betamethasonevalerate(BMV)isasyntheticglucocorticoidthatiscommonlyusedtotreatpsoriasisanddermatitis.BMVexhibitsimmunomodulatory,anti-inflammatory,andvasoconstrictiveactivityinvitroandinvivo.Acrossanimalmodelsofvaryingages,BMVimpairsmaturationandviABIlityofLangerhansandepidermalcells.BMValsodecreasesendogenousphospholipaseactivityandinhibitsvasodilatoryresponsesinskin;thispartialvasoconstrictiondecreasesbloodflow,oftenresultinginadecreaseinlocalTGF-β1levels.
| CasNo. | 2152-44-5 |
|---|---|
| Purity | ≥98% |
| Formula | C27H37FO6 |
| FormulaWt. | 476.58 |
| IUPACName | [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]pentanoate |
| MeltingPoint | 183.5°C |
| Solubility | Insolubleinwater.Ethanol(62mg/mL).Solubleinacetone,DMSO. |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | B1879InfoSheetPDF |
|---|
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LeivoT,ArjomaaP,OivulaJ,etal.Differentialmodulationoftransforminggrowthfactor-betabybetamethasone-17-valerateandisotretinoin:corticosteroiddecreasesandisotretinoinincreasestheleveloftransforminggrowthfactor-betainsuctionblisterfluid.SkinPharmacolApplSkinPhysiol.2000May-Aug;13(3-4):150-6.PMID:10859533.
MarksR,SawyerM.Glucocorticoid-inducedvasoconstrictioninhumanskin.AninhibitoryroleonphospholipaseA2activity.ArchDermatol.1986Aug;122(8):881-3.PMID:2874773.
