LKT/SORAFENIB/S5868/100 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/SORAFENIB/S5868/100 mg

LKT/SORAFENIB/S5868/100 mg

商品编号： S5868-100mg

品牌： lktlabs

市场价： ¥3460.00

美元价： 2076.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDS5868

CasNo.284461-73-0

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Sorafenibisaninhibitorofc-Raf,Ret,andVEGFR2thatiscurrentlyusedclinicallytotreatrenalcellcarcinomaandhepatocellularcarcinoma,aswellasotheradvancedcancers.Sorafenibexhibitsanticancerchemotherapeutic,anti-angiogenic,andimmunosuppressiveactivities.Inosteosarcomacells,sorafenibinhibitscellproliferationbydownregulatingexpressionofERKandVEGFR2andinhibitingphosphorylationofVEGFR2,RET,andMEK1.Incellularandanimalmodelsoflymphoma,sorafenibinhibitsphosphorylationofMAPKsandPI3K/Akt,decreasingvesseldensityandincreasingapoptoticcelldeath.Sorafenibalsoinhibitstheepithelial-to-mesenchymaltransition(EMT)inepithelialcellsandpotentiateshistoneacetylation.Inhepatomacells,thiscompounddecreaseslevelsofenhancerofzestehomolog2(EZH2)andinhibitshistonemethyltransferase(HMT)activity,inducingapoptosis.Inanimalmodels,sorafenibinhibitstumorgrowth,increasestumor-specificTcells,anddecreasesCD8+andTregTcellfunctionsbyinducingTcellapoptosis.Additionally,sorafenibinhibitsphosphorylationofSTAT3/5.

ProductInfo

CasNo.	284461-73-0
Purity	≥98%
Formula	C₂₁H₁₆ClF₃N₄O₃
FormulaWt.	464.82
IUPACName	4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide
Synonym	4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide;BAY43-9006
MeltingPoint	202-204°C
Solubility	DMSO127mg/mL,water:0.01mg/mL
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	S5868MSDSPDF
InfoSheet	S5868InfoSheetPDF

References

MeiJ,ZhuX,WangZ,etal.VEGFR,RET,andRAF/MEK/ERKPathwayTakePartintheInhibitionofOsteosarcomaMG63CellswithSorafenibTreatment.CellBiochemBiophys.2013Dec31.[Epubaheadofprint].PMID:24375110.

ChenML,YanBS,LuWC,etal.Sorafenibrelievescell-intrinsicandcell-extrinsicinhibitionsofeffectorTcellsintumormicroenvironmenttoaugmentantitumorimmunity.IntJCancer.2013Jul2.[Epubaheadofprint].PMID:23818246.

WangS,ZhuY,HeH,etal.Sorafenibsuppressesgrowthandsurvivalofhepatomacellsbyacceleratingdegradationofenhancerofzestehomolog2.CancerSci.2013Jun;104(6):750-9.PMID:23421437.

ZhangJ,ChenYL,JiG,etal.Sorafenibinhibitsepithelial-mesenchymaltransitionthroughanepigenetic-basedmechanisminhumanlungepithelialcells.PLoSOne.2013May31;8(5):e64954.PMID:23741434.

Carlo-StellaC,LocatelliSL,GiacominiA,etal.SorafenibinhibitslymphomaxenograftsbytargetingMAPK/ERKandAKTpathwaysintumorandvascularcells.PLoSOne.2013Apr19;8(4):e61603.PMID:23620775.

PankaDJ,WangW,AtkinsMB,etal.TheRafinhibitorBAY43-9006(Sorafenib)inducescaspase-independentapoptosisinmelanomacells.CancerRes.2006Feb1;66(3):1611-9.PMID:16452220.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂