Spiraprilisanon-sulfhydrylnon-competitiveinhibitorofangiotensin-convertingenzyme(ACE).Spiraprilisusedclinicallyforitsantihypertensiveactivity,loweringtotalperipheralvascularresistanceandbloodpressureandslightlyincreasingcardiacoutputandstrokevolume.
| CasNo. | 94841-17-5 |
|---|---|
| Purity | ≥98% |
| Formula | C22H30N2O5S2•HCl |
| FormulaWt. | 503.07 |
| IUPACName | (8S)-7-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylicacid |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | S6168InfoSheetPDF |
|---|
NobleS,SorkinEM.Spirapril.Apreliminaryreviewofitspharmacologyandtherapeuticefficacyinthetreatmentofhypertension.Drugs.1995May;49(5):750-66.PMID:7601014.
SybertzEJ,WatkinsRW,AhnHS,etal.Pharmacologic,metabolic,andtoxicologicprofileofspirapril(SCH33844),anewangiotensinconvertinginhibitor.JCardiovascPharmacol.1987;10Suppl7:S105-8.PMID:2485040.
