Spironolactoneisadiureticthatinhibitsaldosteronereceptors,mineralocorticoidreceptors,androgenreceptors,andendothelialNa+channels(ENaCs).Spironolactoneexhibitsantihypertensiveactivityandisclinicallyusedtotreatheartfailure.Spironolactonemayinhibitvoltage-gatedCa2+channels.
| CasNo. | 52-01-7 |
|---|---|
| Purity | ≥97% |
| Formula | C24H32O4S |
| FormulaWt. | 416.57 |
| ChemicalName | (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylicacidγ-lactone |
| IUPACName | S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5"-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2"-oxolane]-7-yl]ethanethioate |
| Synonym | Spirolactone;Spiroctan;Aldactone |
| MeltingPoint | 134-135°C(lit.) |
| Solubility | Solubleinorganicsolvents.Practicallyinsolubleinwater. |
| Appearance | Off-WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | S6235InfoSheetPDF |
|---|
YancyCW,JessupM,BozkurtB,etal.2013ACCF/AHAguidelineforthemanagementofheartfailure:areportoftheAmericanCollegeofCardiologyFoundation/AmericanHeartAssociationTaskForceonPracticeGuidelines.JAmCollCardiol.2013Oct15;62(16):e147-239.PMID:23747642.
MannSJ,ParikhNS.AsimplifiedmechaNISTicalgorithmfortreatingresistanthypertension:efficacyinaretrospectivestudy.JClinHypertens(Greenwich).2012Apr;14(4):191-7.PMID:22458739.
NappiJM,SiegA.Aldosteroneandaldosteronereceptorantagonistsinpatientswithchronicheartfailure.VascHealthRiskManag.2011;7:353-63.PMID:21731887.
