LKT/TANSHINONE IIA/T0154/10 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/TANSHINONE IIA/T0154/10 mg

LKT/TANSHINONE IIA/T0154/10 mg

商品编号： T0154-10mg

品牌： lktlabs

市场价： ¥2080.00

美元价： 1248.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDT0154

CasNo.568-72-9

Purity≥93%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

TanshinoneIIAisfoundinSalviaandexhibitsanticoagulant,neuroprotective,cognitionenhancing,anti-atherosclerotic,andanticancerchemotherapeuticactivities.TanshinoneIIAinhibitsplateletaggregation,increasingbleedingtimeinvivo.TanshinoneIIAalsodecreasesTNF-α-inducedexpressionofVCAM-1andICAM-1invitro.InanimalmodelsofAlzheimer’sdisease,tanshinoneIIAdecreaseslearningandmemorydeficitsandsuppressesexpressionofiNOSandmatricmetalloproteinase2(MMP2).Inglioblastomacells,thiscompoundinducesapoptosisanddownregulatesexpressionofSTAT3andIL-6;italsoinhibitsbreastcancertumorgrowthinanimalmodels.TanshinoneIIAinhibitsmonoacylglycerollipase(MAGL).

ProductInfo

CasNo.	568-72-9
Purity	≥93%
Formula	C₁₉H₁₈O₃
FormulaWt.	294.34
ChemicalName	Phenanthro(1,2-b)furan-10,11-dione,6,7,8,9-tetrahydro-1,6,6-trimethyl-
IUPACName	1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione
Synonym	DanShenKetone;TanshinoneII;TanshinoneB
MeltingPoint	198-200°C
Solubility	SolubleinDMSO.
Appearance	Redcrystal

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

MSDS	T0154MSDSPDF
InfoSheet	T0154InfoSheetPDF

References

MaioneF,DeFeoV,CaiazzoE,etal.TanshinoneIIA,amajorcomponentofSalviamilthorrizaBunge,inhibitsplateletactivationviaErk-2signalingpathway.JEthnopharmacol.2014Sep11;155(2):1236-42.PMID:25038434.

YangL,GuoH,DongL,etal.TanshinoneIIAinhibitsthegrowth,attenuatesthestemnessandinducestheapoptosisofhumangliomastemcells.OncolRep.2014Sep;32(3):1303-11.PMID:24970314.

JiangP,LiC,XiangZ,etal.TanshinoneIIAreducestheriskofAlzheimer"sdiseasebyinhibitingiNOS,MMP2andNFκBp65transcriptionandtranslationinthetemporallobesofratmodelsofAlzheimer"sdisease.MolMedRep.2014Aug;10(2):689-94.PMID:24859152.

ChangCC,ChuCF,WangCN,etal.Theanti-atheroscleroticeffectoftanshinoneIIAisassociatedwiththeinhibitionofTNF-α-inducedVCAM-1,ICAM-1andCX3CL1expression.Phytomedicine.2014Feb15;21(3):207-16.PMID:24157079.

LinC,WangL,WangH,etal.TanshinoneIIAinhibitsbreastcancerstemcellsgrowthinvitroandinvivothroughattenuationofIL-6/STAT3/NF-kBsignalingpathways.JCellBiochem.2013Sep;114(9):2061-70.PMID:23553622.

LiW,LiJ,AshokM,etal.Acardiovasculardrugrescuesmicefromlethalsepsisbyselectivelyattentuatingalate-actingproinflammatorymediator,highmobilitygroupbox1.JImmunol.2007Mar15;178(6):3856-3864.PMID:17339485.

ZhangY,WonSH,JiangC,etal.TanshinonesfmorChinesemedicinalherbDanshen(SalviamiltiorrhizaBunge)suppressprostatecancergrowthandandrogenreceptorsignaling.PharmRes.2012Jun;29(6):1595-1608.PMID:22281759.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂