LKT/TANSHINONE IIA/T0154/25 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/TANSHINONE IIA/T0154/25 mg

LKT/TANSHINONE IIA/T0154/25 mg

商品编号： T0154-25mg

品牌： lktlabs

市场价： ¥4340.00

美元价： 2604.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Product ID T0154

Cas No. 568-72-9

Purity ≥93%

Description
Product Info
Shipping and Storage
Downloads
References

Description

Tanshinone IIA is found in Salvia and exhibits anticoagulant, neuroprotective, cognition enhancing, anti-atherosclerotic, and anticancer chemotherapeutic activities. Tanshinone IIA inhibits platelet aggregation, increasing bleeding time in vivo. Tanshinone IIA also decreases TNF-α-induced expression of VCAM-1 and ICAM-1 in vitro. In animal models of Alzheimer’s disease, tanshinone IIA decreases learning and memory deficits and suppresses expression of iNOS and matric metalloproteinase 2 (MMP2). In glioblastoma cells, this compound induces apoptosis and downregulates expression of STAT3 and IL-6; it also inhibits breast cancer tumor growth in animal models. Tanshinone IIA inhibits monoacylglycerol lipase (MAGL).

Product Info

Cas No.	568-72-9
Purity	≥93%
Formula	C₁₉H₁₈O₃
Formula Wt.	294.34
Chemical Name	Phenanthro(1,2-b)furan-10,11-dione, 6,7,8,9-tetrahydro- 1,6,6-trimethyl-
IUPAC Name	1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione
Synonym	Dan Shen Ketone; Tanshinone II; Tanshinone B
Melting Point	198-200°C
Solubility	Soluble in DMSO.
Appearance	Red crystal

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	T0154 MSDS PDF
Info Sheet	T0154 Info Sheet PDF

References

Maione F, De Feo V, Caiazzo E, et al. Tanshinone IIA, a major component of Salvia milthorriza Bunge, inhibits platelet activation via Erk-2 signaling pathway. J Ethnopharmacol. 2014 Sep 11;155(2):1236-42. PMID: 25038434.

Yang L, Guo H, Dong L, et al. Tanshinone IIA inhibits the growth, attenuates the stemness and induces the apoptosis of human glioma stem cells. Oncol Rep. 2014 Sep;32(3):1303-11. PMID: 24970314.

Jiang P, Li C, Xiang Z, et al. Tanshinone IIA reduces the risk of Alzheimer's disease by inhibiting iNOS, MMP 2 and NF κBp65 transcription and translation in the temporal lobes of rat models of Alzheimer's disease. Mol Med Rep. 2014 Aug;10(2):689-94. PMID: 24859152.

Chang CC, Chu CF, Wang CN, et al. The anti-atherosclerotic effect of tanshinone IIA is associated with the inhibition of TNF-α-induced VCAM-1, ICAM-1 and CX3CL1 expression. Phytomedicine. 2014 Feb 15;21(3):207-16. PMID: 24157079.

Lin C, Wang L, Wang H, et al. Tanshinone IIA inhibits breast cancer stem cells growth in vitro and in vivo through attenuation of IL-6/STAT3/NF-kB signaling pathways. J Cell Biochem. 2013 Sep;114(9):2061-70. PMID: 23553622.

Li W, Li J, Ashok M, et al. A cardiovascular drug rescues mice from lethal sepsis by selectively attentuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol. 2007 Mar 15;178(6):3856-3864. PMID: 17339485.

Zhang Y, Won SH, Jiang C, et al. Tanshinones fmor Chinese medicinal herb Danshen (Salvia miltiorrhiza Bunge) suppress prostate cancer growth and androgen receptor signaling. Pharm Res. 2012 Jun;29(6):1595-1608. PMID: 22281759.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂