TerlipressinisasyntheticpeptideagoNISTatvasopressin1receptors(AVPR1)andisclinicallyusedtotreatportalhypertensionbydecreasingportalpressure;itisananalogofvasopressin.Terlipressinisavasopressinanalogthatexhibitsbothvasoconstrictiveandantihypertensiveactivitiesinvariousmodels.Terlipressininducesgastroparesisinvivo,increasingslowwavefrequencyinstomachandintestines.Terlipressinmayalsoimproverenalfunctioninsubjectswithhepatorenalsyndrome.
| CasNo. | 14636-12-5 |
|---|---|
| Purity | ≥95% |
| Formula | C52H74N16O15S2 |
| FormulaWt. | 1227.37 |
| IUPACName | (2S)-1-[(4R,7S,10S,13S,16S,19R)-19-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]pyrrolidine-2-carboxamide |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | T1673MSDSPDF |
|---|---|
| InfoSheet | T1673InfoSheetPDF |
LangeM,VanAkenH,WestphalM,etal.RoleofvasopressinergicV1receptoragonistsinthetreatmentofperioperativecatecholamine-refractoryarterialhypotension.BestPractResClinAnaesthesiol.2008Jun;22(2):369-81.PMID:18683482.
BetrosianAP,AgarwalB,DouzinasEE.Acuterenaldysfunctioninliverdiseases.WorldJGastroenterol.2007Nov14;13(42):5552-9.PMID:17948928.
NowakL,KrólczykG,SobockiJ,etal.Gastricstimulationiseffectiveinreversingvasopressininducedgastroparesis.FoliaMedCracov.2004;45(1-2):71-9.PMID:16276827.
HeinemannA,StauberRE.Effectofterlipressinoninvitrovascularhyporeactivityofportalhypertensiverats.JHepatol.1996Jun;24(6):739-46.PMID:8835750.
