Description
TG100-115isaninhibitorofp110δPI3Kandp110γPI3Kthatexhibitsanti-inflammatoryandanti-asthmaactivities.TG100-115decreasespulmonaryeosinophillevelsandaccumulationofIL-13andmucininanimalmodelsofasthmaandchronicobstructivepulmonarydisorder(COPD),decreasinginflammation.TH100-115alsoinhibitsedemaandinflammationinducedbyVEGFandplateletactivatingfactor(PAF)inotheranimalmodels,decreasingdevelopmentofinfarctsandimprovingcardiacfunction.Asaresultofitscardioprotectiveactivity,TG100-115iscurrentlyinclinicaltrialsasapotentialtreatmenttoreduceacutemyocardialinfarctions.
References
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DoukasJ,WrasidloW,NoronhaG,etal.Isoform-selectivePI3Kinhibitorsasnoveltherapeuticsforthetreatmentofacutemyocardialinfarction.BiochemSocTrans.2007Apr;35(Pt2):204-6.PMID:17371238.
DoukasJ,WrasidloW,NoronhaG,etal.Phosphoinositide3-kinasegamma/deltainhibitionlimitsinfarctsizeaftermyocardialischemia/reperfusioninjury.ProcNatlAcadSciUSA.2006Dec26;103(52):19866-71.PMID:17172449.
