LKT/TIBOLONE/T3305/500 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/TIBOLONE/T3305/500 mg

LKT/TIBOLONE/T3305/500 mg

商品编号： T3305-500mg

品牌： lktlabs

市场价： ¥4960.00

美元价： 2976.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDT3305

CasNo.5630-53-5

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Tiboloneisasyntheticsteroidhormoneselectiveestrogenreceptormodulator(SERM)thatactsasanagoNISTorantagonistdependingonthetissuelocation.Tiboloneexhibitsanti-osteoporotic,vasodilatory,andanti-metastaticactivities.Tibolonehasestrogenicandandrogenicactivityandisusedforhormonereplacementtherapy,preventingbonelossinpostmenopausalwomen;itactsasanagonistatprogesteroneandandrogenreceptors.Tiboloneanditsvariousmetabolitesactonmanyenzymes;theyinhibitSTS,17β-HSD1,andaromatase,andactivatesteroidsulfotransferaseand17β-HSD2.Tiboloneproducesvascularrelaxationincoronaryarteriesaswell.Additionally,thiscompoundinhibitsmammarycarcinomacellinvasion,likelybydecreasingactivityofMMP9.Tiboloneisanantagonistatmineralocorticoidandglucocorticoidreceptors.

ProductInfo

CasNo.	5630-53-5
Purity	≥98%
Formula	C₂₁H₂₈O₂
FormulaWt.	312.45
ChemicalName	(7α,17α)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one
IUPACName	(7R,8R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
Synonym	Org-OD-14;Livial
MeltingPoint	163-169°C
Solubility	Solubleinethanol,DMSO,andDMF.
Appearance	Whiteoroff-whitecrystallinepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	T3305InfoSheetPDF

References

CampisiR,MarengoFD.Cardiovasculareffectsoftibolone:aselectivetissueestrogenicactivityregulator.CardiovascDrugRev.2007Summer;25(2):132-45.PMID:17614936.

RaobaikadyB,ParsonsMF,ReedMJ,etal.Tiboloneanditsdelta-4,7alpha-methylnorethisteronemetabolitearereversIBLeinhibitorsofhumanaromatase.JSteroidBiochemMolBiol.2007May;104(3-5):154-60.PMID:17467267.

VanhoeckeBW,BrackeME,KloosterboerHJ,etal.Tiboloneanditsmetabolitesinhibitinvasionofhumanmammarycarcinomacellsinvitro.Maturitas.2006Jun20;54(3):229-37.PMID:16581209.

LundCO,NilasL,PedersenSH,etal.Tiboloneanditsmetabolitesacutelyrelaxrabbitcoronaryarteriesinvitro.Maturitas.2004Nov15;49(3):179-88.PMID:15488346.

KloosterboerHJ.Tissue-selectivity:themechanismofactionoftibolone.Maturitas.2004Aug30;48Suppl1:S30-40.PMID:15337246.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂