TicagrelorisaclinicallyapprovedreversIBLeplateletaggregationinhibitorthatexhibitsanticoagulantandantithromboticactivities.Ticagrelorisprimarilyusedtoincreasecoronarybloodflowvelocityandtopreventstroke,heartattack,andmyocardialinfarction.Thiscompoundhasarapidonsetandoffsetofactionandhasbeenshowntoactasanucleosideanalogwithanoverallsimilaritytoadenosine;itisanallostericantagoNISTfortheP2Y12ADPreceptor,inhibitingdownstreamfibrinogencross-linkingbetweenplatelets.
| CasNo. | 274693-27-5 |
|---|---|
| Purity | ≥98% |
| Formula | C23H28F2N6O4S |
| FormulaWt. | 522.57 |
| ChemicalName | (1S,2S,3R,5S)-3-[7-[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol |
| IUPACName | (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylsulfanyltriazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol |
| Synonym | AZD-6140 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | T3200MSDSPDF |
|---|---|
| InfoSheet | T3200InfoSheetPDF |
RahmanM,GustafssonD,WangY,etal.TicagrelorreducesneutrophilrecruitmentandlungdamageinaBDominalsepsis.Platelets.2013Jul15.[Epubaheadofprint]PMID:23855479.
WittfeldtA,EmanuelssonH,Brandrup-WognsenG,etal.Ticagrelorenhancesadenosine-inducedcoronaryvasodilatoryresponsesinhumans.JAmCollCardiol.2013Feb19;61(7):723-7.PMID:23312702.
BirkelandK,ParraD,RosensteinR.Antiplatelettherapyinacutecoronarysyndromes:focusonticagrelor.JBloodMed.2010;1:197-219.PMID:22282698.
