TiclopidineisafirstgenerationthienopyridineADP/P2Y12receptorinhibitorthatexhibitsantithromboticandcardioprotectiveactivities.TiclopidinebindstotheP2Y12receptor,preventingchangesintheglycoproteinIIb/IIIaconformationandsuppressingfibrinogen-plateletbinding.Thiscompoundisclinicallyusedtotreatacutecoronarysyndromeandmyocardialinfarction.
| CasNo. | 53885-35-1 |
|---|---|
| Purity | ≥98% |
| Formula | C14H14ClNS•HCl |
| FormulaWt. | 300.25 |
| ChemicalName | 5-[(2-Chlorophenyl)-methyl]4,5,6,7-tetrahydrothieno[3,2-c]pyridinehydrochloride |
| IUPACName | 5-[(2-chlorophenyl)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine;hydrochloride |
| Synonym | Panaldine;TIclid;Ticlodix;Ticlodone;Caudaline |
| MeltingPoint | 190°C |
| Solubility | Solubleinethanol,methanolorchloroform. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | T3310MSDSPDF |
|---|---|
| InfoSheet | T3310InfoSheetPDF |
CohenMV,DowneyJM.CombinedcardioprotectantandantithromboticactionsofplateletP2Y12receptorantagoNISTsinacutecoronarysyndrome:justwhatthedoctorordered.JCardiovascPharmacolTher.2014Mar;19(2):179-90.PMID:24298192.
SeccoGG,ParisiR,MirabellaF,etal.P2Y12inhibitors:pharmacologicmechanismandclinicalrelevance.CardiovascHematolAgentsMedChem.2013Jun;11(2):101-5.PMID:22963529.
