TolvaptanisaninhibitorofthevasopressinreceptorsubtypeV2;itactsasadiuretic,inhibitingreabsorptionofwaterinthekidneywithoutlossofsodium.Tolvaptanisaclinicallyeffectivediureticusedincongestiveheartfailure(CHF)andseverechronickidneydiseasethatdoesnotinducehypernatremia.Thiscompoundcanalsobeusedtotreatthesevereorchronichyponatremiastemmingfromsyndromeofinappropriateantidiuretichormonesecretion(SIADH)thatoccursaftertraumaticbraininjury.
| CasNo. | 150683-30-0 |
|---|---|
| Purity | ≥98% |
| Formula | C26H25ClN2O3 |
| FormulaWt. | 448.94 |
| ChemicalName | N-(4-{[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide |
| IUPACName | N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide |
| Synonym | OPC-41061 |
| MeltingPoint | 226°C |
| Appearance | Off-whitetoyellowpowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | T5847MSDSPDF |
|---|---|
| InfoSheet | T5847InfoSheetPDF |
OtsukaT,SakaiY,OhnoD,etal.Theeffectsoftolvaptanonpatientswithseverechronickidneydiseasecomplicatedbycongestiveheartfailure.ClinExpNephrol.2013Mar13.[Epubaheadofprint].PMID:23483323.
GrazianiG,CucchiariD,AroldiA,etal.Syndromeofinappropriatesecretionofantidiuretichormoneintraumaticbraininjury:whentolvaptanbecomesalifesavingdrug.JNeurolNeurosurgPsychiatry.2012May;83(5):510-2.PMID:22323742
GheorghiadeM,TeerlinkJR,MebazaaA.Pharmacologyofnewagentsforacuteheartfailuresyndromes.AmJCardiol.2005Sep19;96(6A):68G-73G.PMID:16181825.
