Description
Torsemide is a pyridine-sulfonyl urea loop diuretic known for its antihypertensive and cardioprotective activities. This compound acts as a competitive inhibitor of the Na+-K+-2Cl- symporter in the loop of Henle by binding directly to the Cl- binding site; this inhibition prevents reabsorption of Na+, Cl-, Mg2+, and Ca2+, resulting in a decrease in blood volume and pressure. Torsemide treats edema, hypertension, and congestive heart failure, attenuating left ventricular cardiac remodeling. This compound also inhibits aldosterone secretion and ATPase activity of HSP90.
References
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Kasama S, Toyama T, Hatori T, et al. Effects of torasemide on cardiac sympathetic nerve activity and left ventricular remodelling in patients with congestive heart failure. Heart. 2006 Oct;92(10):1434-40. PMID: 16621879.
Goodfriend TL, Ball DL, Oelkers W, et al. Torsemide inhibits aldosterone secretion in vitro. Life Sci. 1998;63(3):PL45-50. PMID: 9698054.
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