LKT/TRANDOLAPRIL/T6803/25 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/TRANDOLAPRIL/T6803/25 mg

LKT/TRANDOLAPRIL/T6803/25 mg

商品编号： T6803-25mg

品牌： lktlabs

市场价： ¥1920.00

美元价： 1152.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDT6803

CasNo.87679-37-6

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Trandolaprilisaninhibitorofangiotensin-convertingenzyme(ACE)thatisusedtotreatcongestiveheartfailure(CHF).Trandolaprilexhibitsantihypertensive,neuroprotective,andcardioprotectiveactivities.Trandolaprilinhibitsexpressionofmatrixmetalloproteinases2and9(MMP2/MMP9)inamiddlecerebralarteryocclusionmodelofcerebralischemia.Inotheranimalmodels,trandolaprildecreasesmyocardialbradykininandeNOSexpressioninaorticendotheliumandcardiacmyocytes.Additionally,thiscompoundpreventsleftventricularpressurechangesandhypertrophyassociatedwithCHFandmyocardialinfarction.Trandolaprilattenuatescardiacdysfunctioninducedbyheartfailure,decreasingmeanarterialpressure(MAP)andleftventricularsystolicpressureandalsominimizingheartfailure-induceddecreasesincardiacoutputandstrokevolume.

ProductInfo

CasNo.	87679-37-6
Purity	≥98%
Formula	C₂₄H₃₄N₂O₅
FormulaWt.	430.54
IUPACName	(2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylicacid
MeltingPoint	119-123°C
Solubility	Solubleinmethanol,dichloromethane,DMSO,andethanol
Appearance	WhiteCrystalPowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	T6803InfoSheetPDF

References

TanakaH,TakaiS,JinD,etal.Inhibitionofmatrixmetalloproteinase-9activitybytrandolaprilaftermiddlecerebralarteryocclusioninrats.HypertensRes.2007May;30(5):469-75.PMID:17587759.

ToyoshimaH,NasaY,KohsakaY,etal.TheeffectofchronictreatmentwithtrandolapriloncyclicAMP-andcyclicGMP-dependentrelaxationsinaorticsegmentsofratswithchronicheartfailure.BrJPharmacol.1998Jan;123(2):344-52.PMID:9489624.

SanbeA,TanonakaK,KobayasiR,etal.Effectsoflong-termtherapywithACEinhibitors,captopril,enalaprilandtrandolapril,onmyocardialenergymetabolisminratswithheartfailurefollowingmyocardialinfarction.JMolCellCardiol.1995Oct;27(10):2209-22.PMID:8576937.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂